仿生材料与组织工程研究团队
科研团队：仿生材料与组织工程研究团队
团队网站：https://www.x-mol.com/groups/BMTEers
一、团队研究方向：
南通大学“仿生材料与组织工程研究”团队的主要研究方向为：1. 临床生物医用材料与体外诊断试剂的研发；2. 功能复合材料；3. 仿生材料与组织工程；4. 药物可控缓释系统。团队围绕材料学、细胞与分子生物学、临床医学等多学科交叉，以仿生生物医用材料为工具重点探索支架与（干）细胞/组织相互作用机制、疾病诊断、药物可控释放系统、再生医学方面的基础和应用研究。
二、团队负责人简介
袁卉华博士, 副教授（校聘教授）, 硕士生导师。江苏省“六大人才高峰”高层次人才培养对象。现任SCI期刊 Frontiers in Bioengineering and Biotechnology（IF=6.064, 二区）副主编（Associate Editor 生物材料类），曾任SCI期刊Biomimetics 客座编辑（IF=3.743, 三区）。在生物材料、纳米技术、高分子复合材料等领域的学术刊物上发表SCI论文45篇（其中以第一或通讯作者发表SCI论文27篇，中科院一区论文12篇，二区论文9篇），获选SCI 期刊编辑的重点推荐（Editor’s Pick）及特色文章（Featured articles）1篇（Biomed Mater 2014, 9(5):055001），目前SCI论文被引用达1900余次，H-指数23（谷歌学术数据），第一作者撰写英文专著的1个章节，获授权15项中国发明专利。中国生物材料学会、中国生物医学工程学会、中国化学会以及国际组织工程与再生医学会员，也是Adv Funct Mater, Adv Sci, ACS Nano, Small等一区TOP国际学术期刊的受邀论文评审人。近年来，承担国家、江苏省、南通市科技计划项目等10余项课题。
三、团队成员
教师
李碧云 博士、高级实验师
薛也 博士、讲师（校聘副教授）
宣红云 博士、讲师
金艳 博士、讲师
研究生
熊峰、吴淑嫄、杜茜、魏硕、张卓君、刘向艳、蒋伟、陈瑶
本科生
黄宇婷、杨舒文、华馨丽、李念慈、李瑞萌、孙莉、孙芸倩、王左阳、吴怡佳、崔文卓、刘子豪、赵文博、苟亚婷、罗凯文、沈筱妮、张馨尹、赵爽、周娇、程策昊
四、科研项目
2019-2021: 国家自然科学基金-青年项目：肌腱再生（袁卉华）
2021-2023: 国家自然科学基金-青年项目：神经再生（宣红云）
2020-2023: 江苏省自然科学基金-青年基金项目：神经再生（宣红云）
2018-2021: 江苏省自然科学基金-青年基金项目：肌腱再生（袁卉华）
2018-2020: 江苏省“六大人才高峰”高层次人才项目：肌腱再生（袁卉华）
2020-2023: 江苏省高校自然科学研究面上项目：神经再生（宣红云）
2022-2024：南通市科技项目：骨再生（袁卉华）
2021-2023: 南通市科技项目：神经再生（薛也）
2021-2023: 南通市科技项目：神经性疾病调控机制（金艳）
2019-2021: 南通市科技项目：气管软骨再生（李碧云）
2019-2021: 南通市科技项目：神经再生（宣红云）
2017-2019: 南通市科技项目：肌腱再生（袁卉华）
五、近5年主要论文及著作
1. Hongyun Xuan#, Qian Du#, Ruimeng Li, Xiaoni Shen, Jiao Zhou, Biyun Li, Yan Jin*, Huihua Yuan*. Shape-Memory-Reduced Graphene/Chitosan Cryogels for Non-Compressible Wounds. International Journal of Molecular Sciences, 2023, 24, 1389.
2. Biyun Li, Xiaoxiao Gao,Jiangang Qu, Feng Xiong, Hongyun Xuan, Yan Jin*, Huihua Yuan*. Visible-light-driven antimicrobial activity and mechanism of polydopamine-reduced graphene oxide/BiVO4 Composite. International Journal of Molecular Sciences, 2022, 23(14):7712.
3. Shuyuan Wu, Zhuojun Zhang, Ran Xu, Shuo Wei, Feng Xiong, Wenzhuo Cui, Biyun Li,Ye Xue*, Hongyun Xuan*, Huihua Yuan*. A spray-filming, tissue-adhesive, and bioactive polysaccharide self-healing hydrogel for skin regeneration. Materials & Design, 2022, 217:110669.
4. Feng Xiong, Shuo Wei, Han Sheng, Xiang Han, Wei Jiang, Zhuojun Zhang, Biyun Li, Hongyun Xuan, Ye Xue*, Huihua Yuan*. In situ polydopamine functionalized poly-L-lactic acid nanofibers with near-infrared-triggered antibacterial and reactive oxygen species scavenging capability.International Journal of Biological Macromolecules, 2022, 201:338-350.
5. Xiaolei Li#, Feng Xiong#, Shuguang Wang, Zhuojun Zhang, Jihang Dai, Hui Chen, Jingcheng Wang, Qiang Wang*, Huihua Yuan*. N-acetyl-cysteine-loaded biomimetic nanofibrous scaffold for osteogenesis of induced-pluripotent-stem-cell-derived mesenchymal stem cells and bone regeneration. Frontiers in Bioengineering and Biotechnology, 2021, 9:767641.
6. Hongyun Xuan#, Shuo Wei#, Feng Xiong, Zhuojun Zhang, Ye Xue, Miao Sun*, Biyun Li*, Huihua Yuan*. Design of porous and fish scale-like nanofibers for the reinforcement of transparent composites. Materials & Design, 2021, 212:110284.
7. Cong Gao, Shuai Lu, Yongzhou Wang, Hao Xu, Xiaoxiao Gao, Yiwen Gu, Hongyun Xuan, Baohua Wang*, Huihua Yuan*, Yunying Cao*. Bismuth vanadium oxide can promote growth and activity in Arabidopsis thaliana. Frontiers in Chemistry, 2021, 9:766078.
8. Hongyun Xuan, Shuyuan Wu, Simiao Fei, Biyun Li, Yumin Yang*, Huihua Yuan*. Injectable nanofiber-polysaccharide self-healing hydrogels for wound healing. Materials Science & Engineering C, 2021, 128: 112264.
9. Biyun Li, Shuo Wei, Hongyun Xuan, Ye Xue, Huihua Yuan*. Tailoring fineness and content of nylon-6 nanofibers for reinforcing optically transparent poly(methyl methacrylate) composites. Polymer Composites, 2021, 1-10.
10. Hongyun Xuan#, Biyun Li#, Feng Xiong, Shuyuan Wu, Zhuojun Zhang, Yumin Yang*, Huihua Yuan*. Tailoring nano-porous surface of aligned electrospun poly(L-lactic acid) fibers for nerve tissue engineering. International Journal of Molecular Science, 2021, 22:3536.
11. Huihua Yuan#,*, Xiaolei Li#, Ming-Song Lee, Zhuojun Zhang, Biyun Li, Hongyun Xuan, Wan-Ju Li , Yanzhong Zhang*.Collagen and chondroitin sulfate functionalized bioinspired fibers for tendon tissue engineering application. International Journal of Biological Macromolecules, 2021, 170:248-260.
12. Ye Xue, Krista Jackson, Natalie Page, Xiaoyang Mou, Samuel Lofland, Xiao Hu*. Water-annealing regulated protein-based magnetic nanofiber materials: tuning silk structure and properties to enhance cell response under magnetic fields, Materials Today Chemistry, 2021, 22: 100570.
13. Biyun Li#, Yinhu Liu#, Shuo Wei, Yuting Huang, Shuwen Yang, Ye Xue, Hongyun Xuan, Huihua Yuan*. A solvent system involved fabricating electrospun polyurethane nanofibers for biomedical applications. Polymers, 2020, 12:3038.
14. Biyun Li#, Feng Xiong#, Bo Yao, Qian Du, Jun Cao, Jiangang Qu, Wei Feng*, Huihua Yuan*. Preparation and characterization of antibacterial dopamine-functionalized reduced graphene oxide/PLLA composite nanofibers. RSC Advances, 2020,10:18614-18623.
15. Hongyun Xuan, Xiaoxuan Tang, Yanxi Zhu, Jue Ling*, Yumin Yang*. Freestanding hyaluronic acid/silk-based self-healing coating towards tissue repair with antibacterial surface. ACS Applied Bio-materials, 2020,3(3):1628-1635.
16. Ye Xue, Sam Lofland, Xiao Hu*. Protein-based flexible thermal conductive materials with continuous network structure: fabrication, properties, and theoretical modeling, Composites Part B Engineering, 2020, 201(49): 108377.
17. Ye Xue, Sam Lofland, Xiao Hu*. Comparative study of silk-based magnetic materials: effect of magnetic particle types on the protein structure and biomaterial properties, International Journal of Molecular Sciences, 2020, 21(20): 7583.
18. Ye Xue, Xiao Hu*. Electrospun silk-boron nitride nanofibers with tunable structure and properties, Polymers, 2020, 12(5): 1093.
19. Hao Chen#, Biyun Li#, Bei Feng, Hao Wang, Huihua Yuan*, Zhiwei Xu*. Tetracycline hydrochloride loaded citric acid functionalized chitosan hydrogel for wound healing. RSC Advances, 2019, 9(34):19523-19530.
20. Hongyun Xuan, Yanxi Zhu, Jiaoyu Ren, Wei Dai, Liqin Ge*. Self-healing, antibacterial, and dual cross-linked multilayer films for microcapsule-based controllable drug release applications. Applied Surface Science, 2019, 476: 182-188.
21. Hongyun Xuan, Yanxi Zhu, Jiaoyu Ren, Liqin Ge*. Intrinsic self-healing and biocompatibility of carbon nitride coatings via inhibiting or degrading ethylene for fruit preservation. Journal of materials science, 2019, 54: 9282-9290.
22. Ye Xue#, Fang Wang#, Maria Torculas, Samuel Lofland, Xiao Hu*. Formic acid regenerated mori, tussah, eri, thai, and muga silk materials: mechanism of self-assembly, ACS Biomaterials Science & Engineering, 2019, 5(12): 6361-6373.
23. Hao Chen#, Hao Wang#, Biyun Li#, Bei Feng, Xiaomin He, Wei Fu, Huihua Yuan*, Zhiwei Xu*. Enhanced chondrogenic differentiation of human mesenchymal stems cells on citric acid-modified chitosan hydrogel for tracheal cartilage regeneration applications. RSC Advances, 2018, 8(30): 16910-16917.
24. Hongyun Xuan, Wei Dai, Yanxi Zhu, Jiaoyu Ren, Jianhao Zhang, Liqin Ge*. Self-Healing, antibacterial and sensing nanoparticle coating and its excellent optical applications. Sensors and actuators B: Chemical, 2018, 257:1110-1117.
25. Hongyun Xuan, Jiaoyu Ren, Xizhang Wang, Jianhao Zhang, Liqin Ge*. Flame-retardant, non-irritating and self-healing multilayer films with double-network structure. Composites Science and Technology, 2017, 145: 15-23.
26. Hongyun Xuan, Jiaoyu Ren, Jianhao Zhang, Liqin Ge*. Novel highly-flexible, acid-resistant and self-healing host-guest transparent multilayer films. Applied Surface Science, 2017, 411: 303-314.
27. Ye Xue, Dave Jao, Wenbing Hu, Xiao Hu*. Silk-silk blend materials, Journal of Thermal Analysis and Calorimetry, 2017, 127(1): 915-921.
Book Chapter
1. Huihua Yuan#, Qihui Zhou#, Yanzhong Zhang*, 6. Improving fiber alignment during electrospinning, in Electrospun nanofibers, Editor: Mehdi Afshari, Woodhead Publishing, 2017. ISBN: 9780081009079.
六：指导学生获奖情况
1. 指导2020、2021级硕士研究获江苏省研究生创新基金项目资助2项。
2. 指导2020级硕士研究生获2021年江苏省化工新材料研究生学术创论坛优秀墙报奖1项。
3. 指导2017级生物技术、生物工程本科生完成国家级大创项目1项。
4. 指导2018级海洋技术本科生获2022全国生命科学竞赛江苏赛区三等奖一项。
5. 指导2020届、2021届生物科学、生物工程本科生获江苏省普通高校本专科优秀毕业设计（论文）三等奖2项。
七、联系方式以及其它信息
Email: yuanhh@ntu.edu.cn
欢迎感兴趣的青年人才和同学加入！